Decoding Non-Viral Modalities: Advanced Characterization of Targeted Gene Delivery Systems

1.) Course Description

This workshop examines modern chromatographic techniques for analyzing non-viral drug formulations. Participants will learn about multidimensional chromatography systems that improve analytical workflows and enhance understanding of organ targeting with LNP-based formulations.

2.) Who Should Attend?

◾︎ Researchers and scientists in gene therapy, RNA delivery, and nanoparticle pharmaceuticals seeking analytical advances
◾︎ Manufacturers needing analytical support for quality attributes from DNA through finished drug product
◾︎ Formulation professionals working with nucleic acids and lipid nanoparticle technologies
◾︎ Quality control professionals interested in advanced chromatography for biopharmaceutical characterization

3.) Key Learnings

◾︎ Innovative analytical methods for understanding particle heterogeneity, nucleic acid content, and lipid composition
◾︎ Analysis of multiple cargo formulations including CAR-T therapies, CRISPR gene editing, and vaccines; determination of critical quality attributes
◾︎ Chromatographic techniques for isolating LNP-protein corona complexes and analyzing their composition and biodistribution relationships
◾︎ Latest data analysis software (PATfix) to support analytical efforts